Protein Structure Prediction by Evolutionary Multi-objective Optimization: Search Space Reduction by Using Rotamers
نویسندگان
چکیده
The protein structure prediction (PSP) problem is considered an open problem as there is no recognized ”best” procedure to find solutions. Moreover, this problem presents a vast search space and the analysis of each protein conformation requires significant amount of computing time. We propose a reduction of the search space by using the dependent rotamer library. Also this work introduces new heuristics to improve the multi-objective optimization approach to this problem.
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تاریخ انتشار 2009